Novel therapies emerging in oncology to target the TGF-β pathway
Apr 6, 2021 · Agents in clinical development to target the TGF-β pathway in oncology Despite significant advancements in the …
The ceRNA network of LINC00536/miR-204-5p/TGFBR2: A
Jan 1, 2026 · Conclusions LINC00536 promotes BC progression and activates TGF-β signaling via miR-204-5p/TGFBR2, with its …
MA11.01 Phase 1 Study of DLL3-Targeted CAR-T Cells Armored With ...
Oct 1, 2025 · DLL3 is a validated target in small-cell lung cancer (SCLC) and high-grade neuroendocrine tumors. LB2102 comprises …
Cancer Environment Immunotherapy: targeting TGF-β finds its
Jan 29, 2021 · By specifically depleting TGF-β receptor 2 (TGFBR2) in CD4 + or CD8 + T cells from MMTV-PyMT transgenic mice …
Cancer immunotherapy via targeted TGF-β signalling blockade in T
Oct 21, 2020 · In a mouse model of breast cancer resistant to immune-checkpoint or anti-VEGF therapies10,11, inducible genetic …
TGF-β biology in cancer progression and tumor immunotherapy
TGF-β signaling plays key roles in cancer progression. Most carcinoma cells have inactivated their epithelial antiproliferative …
GABPA-activated TGFBR2 transcription inhibits aggressiveness but is ...
TGFBR2 was identified as the GABPA target gene through which GABPA governed the TGFβ signaling to dictate ccRCC …
An open-label, phase 1, multicenter study to evaluate the safety and ...
May 29, 2024 · Despite its well-established target role in tumorigenesis, there is no FDA-approved therapy targeting the G12D …
Recent advances in therapeutic use of transforming growth ... - Frontiers
Apr 25, 2025 · However, there are challenges in the development of antisense oligonucleotides as a therapeutic target, including off …
TGF-β Signaling in Cancer: Mechanisms of Progression and ... - MDPI
Jul 29, 2025 · TGF-β signaling is a challenging target due to its dual role and pleiotropic nature, suggesting that patient selection and …