Cardiovascular disease continues to lead as the primary cause of death across the globe, taking millions of lives every year. Damage caused by these diseases is particularly difficult to repair, since ...
In summary, macrophages secrete IFN-β, activating the IFN-β-IFNAR-p-STAT1 axis in MICFs, leading to increased secretion of CCL2/7/12 chemokines and subsequent recruitment of more IFN-β-secreting ...
The treatment, currently designated HTX-001, is an antisense oligonucleotide, or ASO, that targets Wisper and reduces the ...
HOUSTON, May 04, 2026 (GLOBE NEWSWIRE) -- FibroBiologics, Inc. (Nasdaq: FBLG) ("FibroBiologics"), a clinical-stage biotechnology company with 270+ patents issued and pending with a focus on the ...
The research uncovers a previously unappreciated mechanism by which macrophages influence the fate of CFs post-MI. It demonstrates that macrophage-derived IFN-β stimulates the IFN-β-IFNAR-p-STAT1 axis ...
Human-induced pluripotent stem cells (hiPSCs) can differentiate into various tissues, an invaluable characteristic for personalized regenerative medicine, basic and translational research, and drug ...
Metabolic reprogramming in fibrotic lung diseases involves key metabolites like lactate, succinate, and 2-hydroxyglutarate, driving inflammation and fibroblast activation. Lactate accumulation ...
The researchers' success in direct reprogramming of mouse fibroblasts into alveolar epithelial-like cells may lead to new treatments for serious lung diseases. Researchers in Japan have successfully ...
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